Dr. Cortner has been unsuccessfully experimenting with transplant surgery, as evidenced by the hideous mutilations of his lab assistant. When Cortner's fiance' is decapitated in a car accident, he saves her head and keeps it alive through freakish means. Through the electrodes and wires, Jan begs to be unplugged so she can die, but her fiance' has other plans. He prowls strip joints for a body to match the head of his girlfriend. Meanwhile, Jan develops a psychic connection with one of the doctors failed experiments. A mutant monster caged in a closet which becomes under the control of 'The Brain That Wouldn't Die.'